2018 Kyoto Prize Laureates

Advanced Technology

Biotechnology and Medical Technology

Karl Deisseroth

/  Neuroscientist

1971 -

Professor and Howard Hughes Medical Institute Investigator, Stanford University

Commemorative Lectures

Optogenetics: Studying Proteins from Single-celled Algae to Illuminate the Mysteries of the Brain


11 /11 Sun

Place:Kyoto International Conference Center


Causal Approaches to Brain Functions Through Optogenetics and Beyond


11 /14 Wed

Place:Tetsumon Memorial Auditorium, Faculty of Medicine, The University of Tokyo

Achievement Digest

Discovery of Optogenetics and Development of Causal Systems Neuroscience

Dr. Deisseroth focused on microbial light-activated proteins such as channelrhodoposin of green algae and spearheaded “optogenetics”—a new methodological discipline in which neurons can be activated or inhibited on the millisecond scale using light. This achievement has revolutionized the field of systems neuroscience, enabling causal study of neuronal assembly activity and resulting function, beyond correlational studies.


Dr. Karl Deisseroth has spearheaded “optogenetics,” a new methodological discipline in which cellular activity is controlled by light, and has revolutionized systems neuroscience research. As a result, he has successfully developed a novel and universal technique to manipulate brain activity at the circuit level and causally manipulate dynamic cellular ensemble activities to demonstrate their necessity and sufficiency in brain functions.

Before optogenetics, systems neuroscience research was primarily based on correlation between neuronal activities and animal behaviors. To address their causality, a variety of techniques were tried also in conventional methodologies, however, the optogenetic method has been transformative in that it can activate and inhibit, with a time resolution of milliseconds, activities of specific neurons identified by molecular markers. He has, to date, made three essential contributions to the field of optogenetics.

Firstly, he demonstrated that channelrhodopsin-2, a light-activated ion channel of green algae, is a molecular device that can control action potential firing in the mammalian brain on the millisecond scale (1). This proved to be a groundbreaking discovery. Successively, he and his colleagues improved in optogenetically evoking and suppressing neural firing by modifying the molecule, or through developing new actuator molecules (2–5, see also 6, 7). Furthermore, by making full use of genetic engineering , he made it possible to study neuronal circuit dynamics in brain regions of interest in vivo (8, 9). More than a thousand laboratories around the world thus begun to perform manipulative interrogation of neuronal circuits. The optogenetics led to more frequent use of rodents as animal models in systems neuroscience research.

Secondly, by utilizing the capability of optogenetics to artificially trigger brain activity, he and his collaborators implemented optical intervention as a means for elucidating higher brain functions, such as learning and memory (10), fear and anxiety (11), reward and pleasure (9), as well as decision-making (12). Although there is no guarantee that all the optogenetically-inducible neuronal activities correspond to naturally-occurring brain activities, optogenetics has demonstrated that a particular activity pattern of neuronal ensembles is sufficient for the execution of a particular brain function, thus providing a novel framework for a causal systems neuroscience.

Thirdly, he obtained data which reinforce the hypothesis that the pathological basis of various neurodegenerative diseases and psychiatric disorders lies in the malfunction of neuronal circuit activity. This consequently led to recent expansion of CNS drug screen targets from “specific molecular pathways” to “pathology-associated neuronal circuit activities”, paving the way for new drug discovery (13, 14).

Dr. Deisseroth not only led innovative research during the early period of the optogenetics but also shared the resources or experimental protocols with the research community and intensively disseminated them. The results of his research have been published in numerous journals, and he has been honored with many awards. On his own, Dr. Deisseroth has also co-founded a drug discovery startup focusing on the utilization of the optogenetics. He also organizes many workshops or training courses in his laboratory, where he welcomes young researchers aspiring to study optogenetics. All these efforts have helped spread the technological advance and have tremendously contributed to pushing the frontiers of neuroscientific research.

For these reasons, the Inamori Foundation is pleased to present the 2018 Kyoto Prize in Advanced Technology to Dr. Karl Deisseroth.

(1) Boyden ES, et al. (2005) Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci 8: 1263–1268.
(2) Zhang F, et al. (2007) Multimodal fast optical interrogation of neural circuitry. Nature 446: 633–639.
(3) Gradinaru V, et al. (2007) Targeting and readout strategies for fast optical neural control in vitro and in vivo. J Neurosci 27: 14231–14238.
(4) Gradinaru V, et al. (2008) eNpHR: A Natronomonas halorhodopsin enhanced for optogenetic applications. Brain Cell Biol 36: 129–139.
(5) Gunaydin LA, et al. (2010) Ultrafast optogenetic control. Nat Neurosci 13: 387–392.
(6) Han X & Boyden ES (2007) Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution. PLoS One 2: e299.
(7) Chow BY, et al. (2010) High-performance genetically targetable optical neural silencing by light-driven proton pumps. Nature 463: 98–102.
(8) Sohal VS, et al. (2009) Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature 459: 698–702.
(9) Tsai HC, et al. (2009) Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science 324: 1080–1084.
(10) Liu X, et al. (2012) Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature 484: 381–385.
(11) Tye KM, et al. (2011) Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature 471: 358-362.
(12) Zalocusky, KA et al. (2016) Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making. Nature 531: 642–646.
(13) Kravitz AV, et al. (2010) Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature 466: 622–626.
(14) Yizhar O, et al. (2011) Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 477: 171–178.


Born in Boston, Massachusetts, U.S.A.
Ph.D., Stanford University
M.D., Stanford University
M.D. Internship/Licensure, Stanford University
Psychiatry Residency and Postdoctoral Fellowship, Stanford University
Principal Investigator and Assistant Professor, Departments of Psychiatry and Behavioral Sciences and of Bioengineering, Stanford University
Associate Professor of Bioengineering and of Psychiatry and Behavioral Sciences, Stanford University
Professor of Bioengineering and of Psychiatry and Behavioral Sciences, Stanford University
D.H. Chen Professor, Stanford University
Investigator, Howard Hughes Medical Institute
Selected Awards and Honors
NIH Director’s Pioneer Award
Presidential Early Career Award for Scientists and Engineers
Young Investigator Award, Society for Neuroscience
HFSP Nakasone Award
The Perl-UNC Neuroscience Prize, University of North Carolina
The K-J. Zülch Prize, The Gertrud Reemtsma Foundation
The Brain Prize, The Lundbeck Foundation
The Dickson Prize in Science, Carnegie Mellon University
The Keio Medical Science Prize
The Dickson Prize in Medicine, University of Pittsburgh
BBVA Foundation Frontiers of Knowledge Award in Biomedicine
Breakthrough Prize in Life Sciences
Massry Prize
Harvey Prize, Technion - Israel Institute of Technology
Else Kröner Fresenius Preis für Medizinische Forschung
Canada Gairdner International Award
Leopoldina, National Academy of Medicine, National Academy of Sciences

Profile is at the time of the award.

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