The 2004 Kyoto Prize Workshops
/ Geneticist and Physician
Life Sciences（Molecular Biology, Cell Biology, Neurobiology）
11 /12 Fri
13:00 - 17:30
Address：Takaragaike, Sakyo-ku, Kyoto 606-0001 Japan
Alfred George Knudson, Jr.
Geneticist and Physician
In the early 1970s, Dr. Knudson proposed the “two-hit” hypothesis as a genetic mechanism of carcinogenesis through an elegant statistical analysis of retinoblastoma, a pediatric eye cancer. He soon advanced this hypothesis and reached the concept that mutational changes in “anti-oncogene”, now termed “tumor suppressor gene”, underlie the development of cancer. His “two-hit” hypothesis and the concept of “tumor suppressor” opened a new horizon in modern cancer genetics and played a pivotal role in the major developments in cancer researches.