The 2004 Kyoto Prize Workshops

Two Genetic Hits to Cancer : Past, Present and Future

Alfred George Knudson, Jr.

/  Geneticist and Physician

Basic Sciences

Life Sciences and Medicine(Molecular Biology, Cell Biology, Systems Biology, etc.)


11 /12 Fri

13:00 - 17:30

Place: Kyoto international Conference Hall

Address:Takaragaike, Sakyo-ku, Kyoto 606-0001 Japan



Opening Address Shin-Ichi Nishikawa
(Chairman, Kyoto Prize Selection Committee; Deputy Director, Center for Developmental Biology, RIKEN)
Introduction to the Laureate Makoto Mark Taketo
Laureate Lecture Alfred George Knudson, Jr.
“Lessons from Hereditary Cancer”
Lecture Okio Hino
(Professor, School of Medicine, Juntendo University; Chief, Department of Experimental Pathology, Cancer Institute)
“Hereditary kidney cancer models fitting Knudson’s 2 hit”
Lecture Makoto Mark Taketo
“Characterization of “the second hit” in mouse models of familial adenomatous polyposis: New molecular mechanisms and implication to cancer progression”
Lecture Shunichi Takeda
(Professor, Graduate School of Medicine, Kyoto University)
“Reverse genetic analysis of DNA repair and recombination pathways in the chicken B lymphocyte DT40”
Lecture Hiromu Suzuki
(Instructor, School of Medicine, Sapporo Medical University)
“Epigenetic and genetic events cooperate to promote human colorectal tumorigenesis: A new mechanism of “the second hit””
Q & A Session


Alfred George Knudson, Jr.

Geneticist and Physician

In the early 1970s, Dr. Knudson proposed the “two-hit” hypothesis as a genetic mechanism of carcinogenesis through an elegant statistical analysis of retinoblastoma, a pediatric eye cancer. He soon advanced this hypothesis and reached the concept that mutational changes in “anti-oncogene”, now termed “tumor suppressor gene”, underlie the development of cancer. His “two-hit” hypothesis and the concept of “tumor suppressor” opened a new horizon in modern cancer genetics and played a pivotal role in the major developments in cancer researches.

*This field then was Field of Life Sciences (Molecular Biology, Cell Biology, Neurobiology).


Related information

November 12, 2004
Kyoto international Conference Hall
Coordinator and Moderator
Makoto Mark Taketo (Member, Kyoto Prize Selection Committee; Professor, Graduate School of Medicine, Kyoto University)