2015Advanced TechnologyMaterials Science and Engineering
Toyoki Kunitake photo

Toyoki Kunitake

  • Japan / February 26, 1936
  • Chemist
  • President, Kitakyushu Foundation for the Advancement of Industry, Science and Technology

Pioneering Contributions to the Materials Sciences by Discovering Synthetic Bilayer Membranes and Creating the Field of Chemistry Based on Molecular Self-Assembly

Dr. Kunitake was the first in the world to report that synthetic molecules could spontaneously produce bilayer membranes—a basic structure common to the biological membranes of living cells. His innovative research has helped to illuminate the formation of bilayer membranes as a universal phenomenon not only in aqueous but also in organic solvents for amphiphilic compounds with extensive molecular structures. By systematizing a mechanism of synthetic bilayer membrane formation, he helped to establish the new and promising academic field of chemistry based on molecular self-assembly, which is opening new frontiers in the materials sciences.


Brief Biography

Born in Kurume, Fukuoka, Japan
Ph.D. in Chemistry, University of Pennsylvania
Postdoctoral Fellow, California Institute of Technology
Associate Professor, Faculty of Engineering, Kyushu University
Professor, Faculty of Engineering, Kyushu University
Group Director, Spatio-Temporal Function Materials Research Group, Frontier Research System, RIKEN
Vice President, the University of Kitakyushu
Director, NanoMembrane Technologies, Inc.
President, Kitakyushu Foundation for the Advancement of Industry, Science and Technology

Selected Awards and Honors

The Award of the Society of Polymer Science, Japan
The Chemical Society of Japan Award
SPSJ Award for Outstanding Achievement in Polymer Science and Technology
Medal with Purple Ribbon, Government of Japan
Japan Academy Prize
Person of Cultural Merit, Government of Japan
The Order of the Sacred Treasure, Gold and Silver Star, Government of Japan
Order of Culture, Government of Japan
The Chemical Society of Japan, The Engineering Academy of Japan,

Selected Publications

A Totally Synthetic Bilayer Membrane (T. Kunitake and Y. Okahata), J. Am. Chem. Soc. 99: 3860–3861, 1977.
Formation of Stable Bilayer Assemblies in Water from Single-Chain Amphiphiles. Relationship between the Amphiphile Structure and the Aggregate Morphology (T. Kunitake et al.), J. Am. Chem. Soc. 103: 5401–5413, 1981.
Synthetic Bilayer Membranes: Molecular Design, Self-Organization, and Application (T. Kunitake), Angewandte Chemie International Edition in English 31: 709–726, 1992.
Assembly of Multicomponent Protein Films by Means of Electrostatic Layer-by-Layer Adsorption (Y. Lvov et al.), J. Am. Chem. Soc. 117: 6117–6123, 1995.
Assembling Alternate Dye-Polyion Molecular Films by Electrostatic Layer-by-Layer Adsorption (K. Ariga et al.), J. Am. Chem. Soc. 119: 2224–2231, 1997.

Pioneering Contributions to the Materials Sciences by Discovering Synthetic Bilayer Membranes and Creating the Field of Chemistry Based on Molecular Self-Assembly

In 1977, Dr. Toyoki Kunitake became the first scientist to report that synthetic molecules could spontaneously produce bilayer membranes—a basic structure common to the biological membranes of living cells. His subsequent research established the formation of bilayer membranes as a universal phenomenon, observed not only within water, but also within organic solvents for synthetic amphiphilic compounds with extensive molecular structures. He went on to systematize a mechanism of synthetic bilayer membrane formation through his unique organic-chemistry-based research methodology and further developed techniques to immobilize bilayer membranes and to produce self-assembling materials. In so doing, he helped to open up the new and promising academic field of chemistry based on molecular self-assembly.

Dr. Kunitake’s approach to synthetic bilayer membranes was revolutionary, overturning the previously held assumption that ordered molecular self-organizational structures like biological membranes could be formed only by biolipids. His research made it possible, for the first time, to gain a molecular design-based understanding of how molecular organizational structures and physical properties, which are created in a hierarchical manner through self-assembly, correlate with the molecular structures of components. While extending the formation of molecular self-assembly from aqueous to organic solvents, he generalized the conventional image of hydrophilic and hydrophobic portions of amphiphilic molecules, so we can now think in terms of the larger categories of molecular parts that are solvophilic and solvophobic. Dr. Kunitake also showed that specific interactions among functional groups derived from advanced ordered structures appears in bilayer membranes, thereby establishing a fundamental concept of chemistry based on self-assembly: that such interactions on the molecular level as well as their collective functions may be controlled according to molecular orientation and distribution. Furthermore, he went on to lead innovations in materials science founded on this basic research.

Dr. Kunitake’s major achievements include: (1) He developed various methods for bilayer membrane immobilization, thereby enabling the creation of precisely organized membranes. Bilayer membranes immobilized in this way are used to produce super-laminated solid molecular-oriented film electrodes in fully automated electrolyte analyzers for medical use and in-vitro diagnostic testing. (2) He developed a molecular self-assembly-based synthetic methodology for two-dimensional polymer and two-dimensional ultrathin silica films by using organic molecular assemblies as molds. (3) He recently developed a technique for manufacturing large, free-standing nanostructured thin films, approximately 15 nm thick, which possesses notable strength as well as extreme flexibility. These characteristics had long been sought in the functional membrane field and, at present, there are high expectations for their wide-ranging application, including improvements in fuel cells and solutions to environmental problems.

Through these achievements, Dr. Kunitake has expanded the concept of molecular self-assembly-based chemistry which is widely recognized as one of the most useful concepts in advanced materials design and opened a new frontier in the field of materials science using self-assembly techniques. At the same time, he has trained a number of highly accomplished researchers in these academic fields while making significant contributions to international academic exchange.

For these reasons, the Inamori Foundation is pleased to present the 2015 Kyoto Prize in Advanced Technology to Dr. Toyoki Kunitake.


Abstract of the Lecture

The Road I Have Taken: Spellbound by the Wonders of Research

I spent my younger days as just another ordinary boy. My parents owned a grocery store in Kurume City, Fukuoka Prefecture. My father was intent on giving his children a good education. When I was at my desk, he never told me what to do but, when I wanted to go out and play, he would immediately order me to do chores around the house. I recall that, during my elementary and junior high school years, I often sat at my desk, just to avoid doing household chores. I was a very curious and rather contrary child. As a junior high school student, I developed a love for reading. I would read, behind my parents’ back, anything I could lay my hands on, such as adventure stories.

I never gave serious thought to a career direction until my last year of senior high school, just as I was about to go on to higher education. My father wanted me to become a pharmacist because he saw that as a secure and steady occupation. However, I wasn’t very keen on that line of work, so we reached a compromise whereby I would study applied chemistry in an engineering faculty. When it came time to do my graduation work during my senior year, I conducted research in laboratories for the first time. I would come up with a hypothesis, then run an experiment to test it. If my hypothesis proved to be incorrect, I would develop another hypothesis and try again. This iterative process to solve riddles fascinated me, and made me decide on choosing a career path focused on research and development.

After attaining a Master’s degree from Kyushu University, I had the opportunity to pursue my doctoral studies at the University of Pennsylvania in the United States, on a Fulbright scholarship. That was back in 1960, when there was still a clear gap in living standard between Japan and the U.S.A. Then, I moved to the West Coast to become a Postdoctoral Fellow at the California Institute of Technology, before returning home in 1963 to join the Department of Organic Synthesis in Kyushu University’s Faculty of Engineering, where I would spend the next 36 years, until I reached the mandatory retirement age in 1999.

As a student at Kyushu University, I worked on synthesis of new plastic materials. It was a time of rapid progress in petrochemistry, with new plastics constantly being developed. Synthesis of plastic materials continued to be my research topic as an Associate Professor but I was also interested in the intricate chemical processes that occur within living organisms. I chose enzyme models as my research focus, as that was where my two fields of interest overlapped. As an extension of that research, synthetic bilayer membranes came into being and then developed into chemistry based on molecular assembly.

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Development of Chemistry Based on Molecular Self-Assembly and Its Future Prospects

Thursday, November 12, 2015
Kyoto International Conference Center
Tisato Kajiyama (Chairman, Board of Trustees, and President, Fukuoka Women's University) Kazuyuki Kuroda (Professor, Waseda University) Nobuo Kimizuka (Distinguished Professor, Kyushu University)
Nobuo Kimizuka
Organized by Inamori Foundation
Supported by Kyoto Prefectural Government, Kyoto City Government, NHK
With the cooperation of Japan Oil Chemists' Society, Japan Science and Technology Agency, Japan Society of Coordination Chemistry, The Chemical Society of Japan, The Electrochemical Society of Japan, The Photochemistry Association, The Japan Society for Analytical Chemistry, The Membrane Society of Japan, The Society of Fiber Science and Technology Japan, The Society of Polymer Science, Japan and The Society of Synthetic Organic Chemistry, Japan


Opening Address and Introduction of Laureate Tisato Kajiyama
Laureate’s Lecture Toyoki Kunitake (Laureate in Advanced Technology)
“Synthetic Bilayer Membrane and Molecular Self-Organization”
Lecture Jacob Sagiv (Professor, Department of Materials and Interfaces, Weizmann Institute of Science)
“Patterned Self-Assembled Silane Monolayers:Nanoscale Functional Materials by Design”
Lecture Kazuyuki Kuroda
“Preparation and Developments of Mesoporous Materials Using Molecularly Assembled Structures”
Lecture Marie-Paule Pileni (Distinguished Professor, University P&M Curie)
“Nano-Supra Crystal: a New Challenge”
Closing Address Nobuo Kimizuka