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2004 Kyoto Prize Laureates
Basic Sciences Category
Prize Field: Life Sciences
(Molecular Biology, Cell Biology, Neurobiology)
"For his seminal contribution to the establishment of the theory of the tumor suppressor gene in the mechanism of human carcinogenesis."
Dr. Alfred George Knudson, Jr.
Date of Birth: August 9, 1922
Nationality: American
Geneticist and Physician
Senior Advisor, Fox Chase Cancer Center
| BRIEF BIOGRAPHY |
| 1922 |
Born in Los Angeles, California, U.S.A. |
| 1947 |
Columbia University M.D. |
| 1956 |
California Institute of Technology Ph.D. (Biochemistry & Genetics) |
| 1956-1966 |
Chairman, City of Hope Medical Center |
| 1966-1969 |
Associate Dean, Health Sciences Center, State University of New York at Stony Brook |
| 1969-1976 |
Professor, University of Texas at Houston |
| 1976- present |
Senior Member, Fox Chase Cancer Center (1980-1982 President,
1992- Fox Chase Distinguished Scientist, Senior Advisor to the President) |
| 1976-present |
Adjunct Professor, Pediatrics and Human Genetics, School of Medicine,
University of Pennsylvania |
| SELECTED AWARDS AND HONORS |
| 1988 |
Charles S. Mott Prize, General Motors Cancer Research Foundation, Washington, D.C. |
| 1997 |
Gairdner Foundation International Award, Toronto |
| 1997 |
IBM — Princess Takamatsu Cancer Research Fund Lectureship and Award, Tokyo |
| 1998 |
Albert Lasker Award for Clinical Medical Research |
| Members |
National Academy of Sciences, American Philosophical Society, American Academy of Arts and Sciences |
| SELECTED WORKS |
| 1971 |
Mutation and cancer: statistical study of retinoblastoma, Proc. Natl. Acad. Sci. USA68-4:820-823. |
| 1973 |
Mutation and human cancer, Adv. Cancer Res. 17:317-352. |
| 1976 |
Chromosomal deletion and retinoblastoma (with Meadows, A.T., Nichols, W.W. and Hill, R.), New Engl. J. Med. 295:1120-1123. |
| 1993 |
Antioncogenes and human cancer, Proc. Natl. Acad. Sci. USA 90:10914-10921. |
| 2000 |
Chasing the cancer demon, Annu. Rev. Genet. 34:1-19. |
| 2001 |
Two genetic hits (more or less) to cancer, Nature Reviews 1:157-162. |
| 2003 |
Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer (with Vilenchik, M.M.), Proc. Natl. Acad. Sci. USA100-22:12871-12876. |
| 2003 |
Cancer genetics through a personal retrospectroscope, Genes chromosomes & Cancer 38-4:288-291 (Special Issue for Knudson). |
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